Measurements of T1 and T2 over time in formalin-fixed human whole-brain specimens

Acta Radiol. 1992 Sep;33(5):400-4.


T1 and T2 were measured in 5 formalin-fixed human whole-brain specimens as a function of time. Gray matter/white matter contrast reversal was observed around the 4th day and was considered to be due to the greater decrease in T1 in gray than in white matter. A possible explanation for this is that the decomposition of the myelin phospholipid structure by formalin somewhat counteracts the general reductive effect of the fixation procedure on relaxation times.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Brain / pathology*
  • Female
  • Formaldehyde*
  • Humans
  • In Vitro Techniques
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Time Factors
  • Tissue Fixation / methods*


  • Formaldehyde