Case report: acquired antisocial personality disorder associated with unilateral left orbital frontal lobe damage

J Psychiatry Neurosci. 1992 Sep;17(3):121-5.


We report on our analysis of a patient who developed personality changes which strongly resembled an antisocial personality disorder after surgical resection of a pituitary tumor. Despite behavioral changes that were obvious to friends, family and health care professionals, formal neuropsychological and personality testing revealed no specific cognitive deficits or psychopathology. We hypothesize that damage to a circumscribed region of the left orbitofrontal cortex, illustrated by magnetic resonance imaging, underlies these personality alterations. In contrast to previous reports, which ascribe such personality changes to bilateral frontal lobe injury, we suggest that unilateral frontal lobe damage alone may have resulted in the development of this syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / physiopathology
  • Adenoma / surgery*
  • Adult
  • Antisocial Personality Disorder / diagnosis
  • Antisocial Personality Disorder / physiopathology*
  • Antisocial Personality Disorder / psychology
  • Brain Damage, Chronic / diagnosis
  • Brain Damage, Chronic / physiopathology*
  • Brain Damage, Chronic / psychology
  • Craniotomy
  • Delusions / diagnosis
  • Delusions / physiopathology
  • Delusions / psychology
  • Dominance, Cerebral / physiology*
  • Frontal Lobe / physiopathology*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neurocognitive Disorders / diagnosis
  • Neurocognitive Disorders / physiopathology*
  • Neurocognitive Disorders / psychology
  • Neurologic Examination
  • Neuropsychological Tests
  • Pituitary Neoplasms / physiopathology
  • Pituitary Neoplasms / surgery*
  • Postoperative Complications / diagnosis
  • Postoperative Complications / physiopathology*
  • Postoperative Complications / psychology