Confidence interval estimation of interaction

Epidemiology. 1992 Sep;3(5):452-6. doi: 10.1097/00001648-199209000-00012.


Relative excess risk due to interaction, the proportion of disease among those with both exposures that is attributable to their interaction, and the synergy index have been proposed as measures of interaction in epidemiologic studies. This paper presents the methodology for obtaining confidence interval estimates of these indices utilizing routinely available output from multiple logistic regression software.

MeSH terms

  • Confidence Intervals*
  • Data Interpretation, Statistical
  • Epidemiologic Methods*
  • Humans
  • Regression Analysis