Implantation of p(HEMA)-collagen composite into bone

Biomaterials. 1992;13(9):639-42. doi: 10.1016/0142-9612(92)90033-k.

Abstract

The replacement of bone defects is very important in clinical practice. This study compares biological properties of poly(2-hydroxyethyl methacrylate)-collagen composite with those exhibited by pure p(HEMA), an insoluble fraction of calf skin collagen (ISC-40) and demineralized bone matrix after implantation into pig or dog femurs. The levels of biodegradation or destruction of implants and healing of bone defects were studied using X-ray photography, histology and enzyme histochemistry. The results indicated a significant effect of collagen on biological destruction of the p(HEMA)-composite implants; even a minute amount of collagen influences this process dramatically. A stimulatory action of collagen on new bone formation may be of importance in bone defect healing.

MeSH terms

  • Animals
  • Biocompatible Materials*
  • Bone and Bones / drug effects*
  • Bone and Bones / ultrastructure
  • Cattle
  • Collagen* / ultrastructure
  • Dogs
  • Humans
  • Polyhydroxyethyl Methacrylate*
  • Prostheses and Implants*
  • Prosthesis Failure
  • Swine
  • Swine, Miniature

Substances

  • Biocompatible Materials
  • Polyhydroxyethyl Methacrylate
  • Collagen