Diabetes-related autoantibodies do appear in children with coeliac disease

Acta Paediatr. 1992 Aug;81(8):593-7. doi: 10.1111/j.1651-2227.1992.tb12307.x.


Humoral immune factors related to type 1 diabetes have been investigated in children with coeliac disease. Anti-insulin (IAAb), immunoglobulin (alpha IgAb), islet cell (ICA) and glucagon autoantibodies were examined in 15 children with coeliac disease at diagnosis (group 1), in 15 children with coeliac disease following a gluten-free diet (group 2) and in 30 control patients (groups 3 and 4). IAAb were present in 27% of group 1 and in 20% of group 2 patients and alpha IgAb were significantly increased in group 1 and 2 patients; two patients in group 2 were positive for ICA; none of the coeliac disease patients were positive for anti-glucagon antibodies. The levels of anti-gliadin antibodies in group 1 were positively correlated with those of alpha IgAb. Coeliac disease-related HLA antigens were not correlated with antibody presence. The presence of diabetes-related humoral immune factors in coeliac disease raises the question as to whether or not they are predictive of subclinical pancreatic damage or whether they are simply indicators of a more general autoimmune diathesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antibodies, Anti-Idiotypic / blood*
  • Autoantibodies / blood*
  • Celiac Disease / immunology*
  • Child
  • Child, Preschool
  • Diabetes Mellitus, Type 1 / immunology*
  • Female
  • Gliadin / immunology
  • Glucagon / immunology
  • HLA-DR Antigens / analysis
  • Humans
  • Immunoglobulin A / analysis
  • Immunoglobulin G / analysis
  • Infant
  • Insulin / immunology*
  • Islets of Langerhans / immunology
  • Male
  • Phenotype


  • Antibodies, Anti-Idiotypic
  • Autoantibodies
  • HLA-DR Antigens
  • Immunoglobulin A
  • Immunoglobulin G
  • Insulin
  • Gliadin
  • Glucagon