Antilactoferrin antibody in systemic lupus erythematosus

Br J Rheumatol. 1992 Oct;31(10):669-73. doi: 10.1093/rheumatology/31.10.669.


Lactoferrin is a secondary granule protein of neutrophils. Seventy-nine systemic lupus erythematosus patients who fulfilled the ARA criteria for classification were tested for antibody against human lactoferrin (LF-ab) by ELISA. Thirty-one of these (39.2%) demonstrated elevated levels. There was significant correlation between LF-ab positivity and disease duration. Clinical flare was common with positive LF-ab (P less than 0.05). Disease manifestations were independent of antibody status except for an increased incidence of lymphadenopathy and crescentic gomerulonephritis among those who had LF-ab. No consistent immunofluorescence pattern could be demonstrated on alcohol-fixed neutrophils for the LF-ab positive sera. It is suggested that LF-ab is related to lupus activity, and can be useful as a marker for disease monitoring.

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies / metabolism*
  • Biomarkers / blood
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Lactoferrin / immunology*
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / immunology*
  • Lupus Nephritis / immunology
  • Lymphatic Diseases / etiology
  • Male
  • Middle Aged


  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies
  • Biomarkers
  • Lactoferrin