Increased secretion of interleukin-6 in malignant mesothelioma cells from a patient with marked thrombocytosis

Cancer. 1992 Oct 15;70(8):2105-8. doi: 10.1002/1097-0142(19921015)70:8<2105::aid-cncr2820700816>;2-r.


Background: A high prevalence of thrombocytosis in malignant mesothelioma has been reported, although its pathogenesis remains unknown.

Methods: The case of a patient with marked thrombocytosis in peritoneal malignant mesothelioma is reported. To investigate the cytokines responsible for thrombocytosis in this patient, enzyme-linked immunosorbent assay and immunohistochemical analysis were used.

Results: Tumor cells produced large amounts of interleukin-6 (IL-6) and small amounts of granulocyte macrophage colony stimulating factor (GM-CSF) and monocyte colony stimulating factor (M-CSF). Immunocytochemical staining of tumor cells showed strong positivity for IL-6.

Conclusions: These results indicated that persistent secretion of IL-6 promoted thrombogenesis in this patient.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Interleukin-6 / metabolism*
  • Male
  • Mesothelioma / complications
  • Mesothelioma / metabolism*
  • Mesothelioma / pathology
  • Middle Aged
  • Peritoneal Neoplasms / complications
  • Peritoneal Neoplasms / metabolism*
  • Peritoneal Neoplasms / pathology
  • Thrombocytosis / etiology*


  • Interleukin-6