The Lennox-Gastaut syndrome: electroencephalographic characteristics, clinical correlates, and follow-up studies

Clin Electroencephalogr. 1992 Oct;23(4):180-9. doi: 10.1177/155005949202300407.


Electroencephalographic and clinical findings are reported for 100 patients with the Lennox-Gastaut (LGS) triad of slow bilateral spike and wave (BSW), retardation and multiple seizures. Neurological and mental deficits were frequently observed, especially in patients who developed seizures before age 1 yr. More than half of the patients had focal epileptiform discharges that peaked in occurrence at age 4-6 yrs. EEG follow-up showed that background frequency slowed when patients developed the LGS pattern, and increased after recovery. Only 2 patients developed normal EEGs on follow-up, although 22 patients no longer showed the LGS pattern after an average of 3 yrs 3 mos follow-up.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Electroencephalography*
  • Epilepsy / diagnosis*
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Sleep / physiology
  • Syndrome