Chronic arsenic poisoning masquerading as Landry-Guillain-Barré syndrome

Electromyogr Clin Neurophysiol. 1992 Sep;32(9):419-23.


Acute arsenic intoxication may present as Landry-Guillain-Barré syndrome because of similarities in clinical symptoms involving the gastrointestinal tract, weakness, and sensory symptoms. Electrodiagnostic findings may be similar with demyelinating changes predominating early in both diseases. A case is presented of repeated arsenic poisoning over two years misdiagnosed as Landry-Guillain-Barré syndrome. Proximal F-loop latency (M-wave latency at wrist + F-wave latency at wrist - 2 M-wave latency at axilla) helped to establish the correct diagnosis. Serial electrodiagnostic studies were done documenting the evolution of chronic repeated arsenic poisoning from a picture showing demyelination to one with severe axonal loss.

Publication types

  • Case Reports

MeSH terms

  • Arsenic Poisoning*
  • Chronic Disease
  • Diagnosis, Differential
  • Electromyography
  • Humans
  • Male
  • Middle Aged
  • Polyradiculoneuropathy / diagnosis
  • Polyradiculoneuropathy / physiopathology*
  • Reaction Time / physiology