Lidocaine in refractory status epilepticus: confirmation of efficacy with continuous EEG monitoring

Epilepsia. Sep-Oct 1992;33(5):913-6. doi: 10.1111/j.1528-1157.1992.tb02200.x.


Lidocaine was efficacious in 2 patients with refractory status epilepticus (RSE) unresponsive to several antiepileptic drugs (AEDs), including high-dose barbiturates. We confirmed the efficacy of lidocaine with, for the first time in adults, continuous EEG monitoring. Lidocaine, when properly used, may be a treatment option in RSE.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Electroencephalography / drug effects*
  • Electroencephalography / methods
  • Humans
  • Lidocaine / pharmacology
  • Lidocaine / therapeutic use*
  • Male
  • Monitoring, Physiologic*
  • Pentobarbital / therapeutic use
  • Status Epilepticus / drug therapy*
  • Status Epilepticus / physiopathology


  • Lidocaine
  • Pentobarbital