Striatal dopamine D1-like receptors have higher affinity for dopamine in ethanol-treated rats

Eur J Pharmacol. 1992 May 14;215(2-3):313-6. doi: 10.1016/0014-2999(92)90047-8.


Experiments were carried out with brain tissues of ethanol-experienced (long-term ethanol intake but withdrawn) vs. ethanol-naive animals. The in vitro 3H antagonist binding of [3H]SCH 23390 and of [3H]spiperone to striatal dopamine D1- and D2-like receptors revealed no significant changes in KD and Bmax values. Displacement of the 3H antagonist binding by dopamine indicated high- and low-affinity states, which also showed no significant alteration at the D2-like receptor but a 5-fold increase of dopamine affinity at the high-affinity state of the D1-like receptor of the ethanol-experienced rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzazepines / metabolism
  • Corpus Striatum / drug effects
  • Corpus Striatum / metabolism*
  • Dopamine / metabolism*
  • Ethanol / pharmacology*
  • Male
  • Rats
  • Rats, Wistar
  • Receptors, Dopamine D1 / drug effects
  • Receptors, Dopamine D1 / metabolism*
  • Receptors, Dopamine D2 / drug effects
  • Receptors, Dopamine D2 / metabolism
  • Spiperone / metabolism
  • Substance Withdrawal Syndrome / metabolism


  • Benzazepines
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Ethanol
  • Spiperone
  • Dopamine