Sequence of the vanY gene required for production of a vancomycin-inducible D,D-carboxypeptidase in Enterococcus faecium BM4147

Gene. 1992 Oct 12;120(1):111-4. doi: 10.1016/0378-1119(92)90017-j.


Cloning and nucleotide sequencing identified the vanY gene as a member of the vancomycin-resistance van gene cluster of enterococcal plasmid, pIP816. The vanY gene was necessary for synthesis of the vancomycin-inducible D,D-carboxypeptidase activity previously proposed to be responsible for glycopeptide resistance. However, this activity was not required for peptidoglycan synthesis in the presence of glycopeptides. The deduced product of vanY did not display significant similarity with other D,D-carboxypeptidases.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Drug Resistance, Microbial / genetics
  • Enterococcus faecium / enzymology
  • Enterococcus faecium / genetics*
  • Enzyme Induction
  • Molecular Sequence Data
  • Muramoylpentapeptide Carboxypeptidase / genetics*
  • Vancomycin / pharmacology*


  • Vancomycin
  • Muramoylpentapeptide Carboxypeptidase

Associated data

  • GENBANK/D10365
  • GENBANK/D10366
  • GENBANK/M74891
  • GENBANK/M74892
  • GENBANK/M79309
  • GENBANK/M79310
  • GENBANK/M90357
  • GENBANK/M90647
  • GENBANK/S43297
  • GENBANK/S45911