Complete Sequence of the Major Outer Membrane Protein-Encoding Gene of Chlamydia Trachomatis Serovar Da

Gene. 1992 Oct 12;120(1):129-30. doi: 10.1016/0378-1119(92)90022-h.

Abstract

The complete nucleotide sequence of the gene omp1 encoding the major outer membrane protein (MOMP) of Chlamydia trachomatis serovar Da was determined following amplification by the polymerase chain reaction. The most closely related complete sequence published to date is that encoding the C. trachomatis L1 MOMP. When the L1 and Da MOMP deduced amino acid (aa) sequences were compared, 16 single-aa differences located mostly in the variable domains I, II, and IV were detected. These regions contain the B-cell epitopes. Additional differences were found in the constant domains I and II, thought to participate in the T-cell response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Antigens, Bacterial*
  • Antigens, Surface / chemistry
  • Antigens, Surface / genetics*
  • Bacterial Outer Membrane Proteins / chemistry
  • Bacterial Outer Membrane Proteins / genetics*
  • Bacterial Vaccines
  • Base Sequence
  • Chlamydia trachomatis / genetics*
  • Lipoproteins*
  • Molecular Sequence Data
  • Porins*
  • Sequence Homology
  • Serotyping

Substances

  • Antigens, Bacterial
  • Antigens, Surface
  • Bacterial Outer Membrane Proteins
  • Bacterial Vaccines
  • Lipoproteins
  • OspA protein
  • Porins
  • omp1 protein, Chlamydia trachomatis
  • OspB protein, Borrelia burgdorferi

Associated data

  • GENBANK/D10365
  • GENBANK/D10366
  • GENBANK/M74891
  • GENBANK/M74892
  • GENBANK/M79309
  • GENBANK/M79310
  • GENBANK/M90357
  • GENBANK/S43297
  • GENBANK/S45911
  • GENBANK/X62921