Prenatal cytogenetic diagnosis of 1,400 consecutive amniocenteses

Gynecol Obstet Invest. 1992;34(2):122-3. doi: 10.1159/000292741.

Abstract

We report on the incidence of chromosomal abnormalities in 1,400 amniocenteses. Thirty-one cases (2.21%) were found to have various types of chromosomal abnormality. The majority of abnormal cases (54.84%) were trisomies. All individuals with trisomic fetuses chose to terminate the pregnancy with the exception of one who gave birth to a Down's syndrome child. However, fetuses with apparently balanced translocations were phenotypically normal at birth.

MeSH terms

  • Amniocentesis*
  • Birth Rate
  • Chromosome Aberrations / epidemiology*
  • Chromosome Aberrations / genetics
  • Chromosome Disorders
  • Hospitals, University
  • Humans
  • Incidence
  • Karyotyping
  • New York City / epidemiology
  • Prenatal Diagnosis*