Lymphocytes bearing the gamma delta T-cell receptor in acute toxoplasmosis

Immunology. 1992 Aug;76(4):668-70.


Although the relative and absolute numbers of CD3+ cells (T lymphocytes) were similar in eight children with acquired Toxoplasma gondii infection and 10 uninfected age- and sex-matched healthy controls, the proportion of cells bearing the gamma delta T-cell receptor was significantly higher in the subjects with acute toxoplasmosis. The great majority of gamma delta T cells from the infected patients expressed covalently bound gamma delta chains on their surface, i.e. were BB3+ lymphocytes. Since the gamma delta T-cell subsets exert both restricted and unrestricted major histocompatibility complex cytotoxicity, further research is needed to elucidate the role of gamma delta T cells in the control of this coccidian protozoan infection.

MeSH terms

  • Acute Disease
  • Adolescent
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Receptors, Antigen, T-Cell, gamma-delta / analysis*
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocytes / immunology*
  • Toxoplasmosis / immunology*


  • Receptors, Antigen, T-Cell, gamma-delta