Glisoprenins, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Gliocladium sp. FO-1513. I. Production, isolation and physico-chemical and biological properties

J Antibiot (Tokyo). 1992 Aug;45(8):1202-6. doi: 10.7164/antibiotics.45.1202.

Abstract

Gliocladium sp. FO-1513 was found to produce novel inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT). Two active compounds, designated glisoprenins A and B, were isolated from the culture broth of the producing strain by a conventional method. The IC50 values of glisoprenins A and B for ACAT activity were 46 and 61 microM in an enzyme assay using rat liver microsomes, and 1.2 and 0.57 microM in a J774 macrophage assay, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Fatty Alcohols*
  • Fermentation
  • Mice
  • Mitosporic Fungi / classification
  • Mitosporic Fungi / metabolism*
  • Rats
  • Sterol O-Acyltransferase / antagonists & inhibitors*
  • Sterol O-Acyltransferase / isolation & purification
  • Sterol O-Acyltransferase / pharmacology

Substances

  • Fatty Alcohols
  • glisoprenin A
  • glisoprenin B
  • Sterol O-Acyltransferase