Comparative in-vitro activity of RP 59500 against clinical bacterial isolates

J Antimicrob Chemother. 1992 Jul;30 Suppl A:45-51. doi: 10.1093/jac/30.suppl_a.45.


The activity of RP 59500 against Gram-positive cocci was determined by an agar dilution method and compared with that of erythromycin, cefotaxime and ampicillin. Of the 344 clinical isolates tested, none was resistant to RP 59500; this compound was active both against methicillin-resistant Staphylococcus aureus and against macrolide-resistant Gram-positive cocci. The bactericidal activity of RP 59500 was confirmed by killing curve determinations.

Publication types

  • Comparative Study

MeSH terms

  • Ampicillin / pharmacology
  • Cefotaxime / pharmacology
  • Erythromycin / pharmacology
  • Gram-Positive Cocci / drug effects*
  • Humans
  • In Vitro Techniques
  • Methicillin Resistance
  • Microbial Sensitivity Tests
  • Virginiamycin / pharmacology*


  • Virginiamycin
  • quinupristin-dalfopristin
  • Erythromycin
  • Ampicillin
  • Cefotaxime