With a sample of 64 adult psychiatric patients, we examined the construct validity of the Holden Psychological Screening Inventory (HPSI) for a clinical population. Factor analysis supported the three-dimensional nature of the HPSI and the appropriateness of the instrument's scoring key. Reliability information confirmed the internal consistency of the inventory's scales. Clinical staff ratings were used as criteria, and analyses indicated that HPSI scales demonstrated convergent validity. Overall, findings extend previous nonclinical research on the HPSI and suggest that the instrument possesses construct validity for clinical applications.