Serum adenosine deaminase activity in systemic sclerosis (scleroderma) and related disorders

J Am Acad Dermatol. 1992 Sep;27(3):411-4. doi: 10.1016/0190-9622(92)70209-x.


Background: Adenosine deaminase (ADA) activity in serum is mainly derived from T lymphocytes.

Objective: Our purpose was to clarify the significance of ADA activity in systemic sclerosis (PSS) and related disorders.

Methods: ADA activity was determined with an enzymatic method in 34 patients with PSS, 4 with mixed connective tissue disease (MCTD), 6 with dermatomyositis (DM), 11 with localized scleroderma (LS), and 13 with other collagen diseases.

Results: Serum ADA activity was elevated over the mean (+2 standard deviations) of the control in 85% of the patients with PSS, all with MCTD, 83% of those with DM, and 82% of those with LS. The mean values in 10 PSS patients with anti-topoisomerase I antibodies, 14 patients with anti-RNP antibodies, 12 patients with anticentromere antibodies (ACAs), and 5 patients without antinuclear antibodies (ANAs) were 26.1, 24.9, 22.6, and 16.8 IU/L, respectively. In most cases, except for ACA-positive patients, serum ADA activity changed almost in parallel with ANA titers.

Conclusion: These results support the notion that T cells are involved in the pathogenesis of PSS and related disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Deaminase / blood*
  • Adult
  • Antibodies, Antinuclear / analysis
  • Collagen Diseases / enzymology*
  • Dermatomyositis / enzymology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mixed Connective Tissue Disease / enzymology
  • Scleroderma, Systemic / enzymology*
  • Scleroderma, Systemic / immunology
  • T-Lymphocytes / enzymology
  • T-Lymphocytes / immunology


  • Antibodies, Antinuclear
  • Adenosine Deaminase