4-acetylaplykurodin B and aplykurodinone B, two ichthyotoxic degraded sterols from the Mediterranean mollusk Aplysia fasciata

A Spinella; M Gavagnin; A Crispino; G Cimino; E Martinez; J Ortea; G Sodano

doi:10.1021/np50085a027

4-acetylaplykurodin B and aplykurodinone B, two ichthyotoxic degraded sterols from the Mediterranean mollusk Aplysia fasciata

J Nat Prod. 1992 Jul;55(7):989-93. doi: 10.1021/np50085a027.

Authors

A Spinella¹, M Gavagnin, A Crispino, G Cimino, E Martinez, J Ortea, G Sodano

Affiliation

¹ Istituto per la Chimica di Molecole di Interesse Biologico, C.N.R., Arco Felice, Italy.

PMID: 1402961
DOI: 10.1021/np50085a027

Abstract

Two ichthyotoxic lactones, 4-acetylaplykurodin B [1] and aplykurodinone B [2], were isolated from the external parts of the body of the mollusk Aplysia fasciata. Their structures, determined by spectroscopic and chemical means, are closely related to aplykurodin B [3] previously isolated from Aplysia kurodai. The interconversion of delta- and gamma-lactones in the aplykurodin derivatives has been also investigated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Aplysia / chemistry*
Indans / chemistry*
Indans / isolation & purification
Lactones / chemistry*
Lactones / isolation & purification
Magnetic Resonance Spectroscopy
Molecular Conformation
Molecular Structure
Optical Rotation

Substances

Indans
Lactones
4-acetylaplykurodin B
aplykurodinone B