Synthesis and biological activity of new 1,8-diaza-2,9,10-anthracenetrione derivatives

C Gesto; E de la Cuesta; C Avendaño; F Emling

doi:10.1002/jps.2600810819

Synthesis and biological activity of new 1,8-diaza-2,9,10-anthracenetrione derivatives

J Pharm Sci. 1992 Aug;81(8):815-6. doi: 10.1002/jps.2600810819.

Authors

C Gesto¹, E de la Cuesta, C Avendaño, F Emling

Affiliation

¹ Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.

PMID: 1403729
DOI: 10.1002/jps.2600810819

Abstract

Diels-Alder heterocycloaddition reactions of 2,5,8-quinolinetriones and 1-azadienes afford 1,8-diaza-2,9,10-anthracenetriones, which are simple analogues of the antitumoral antibiotic diazaquinomicin A. Cytotoxicity in this series and antitumor activity of the lead compound, 6-methyl-1,8-diaza-2,9,10-anthracenetrione, are reported.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Anthracenes / chemical synthesis*
Anthracenes / pharmacology
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Quinones / pharmacology
Tumor Cells, Cultured / drug effects

Substances

Anthracenes
Antineoplastic Agents
Quinones
diazaquinomycin A