Macrophage infiltration in the skin of patients with systemic sclerosis

J Rheumatol. 1992 Aug;19(8):1202-6.


We stained skin specimens from 31 patients with systemic sclerosis with monoclonal antibodies to macrophages and T lymphocytes to characterize the cellular infiltrates. Not only T lymphocytes but macrophages were also identified, and macrophages were observed between collagen bundles as well as around skin adnexa and vessels. In addition, the ratio of macrophages to T lymphocytes was high, particularly in severely affected skin. There was no close relationship with disease duration. Our results suggest that cutaneous macrophages always play a role in scleroderma.

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Monoclonal / immunology
  • Cell Count
  • Cell Movement / physiology
  • Female
  • Humans
  • Macrophages / immunology
  • Macrophages / pathology*
  • Macrophages / physiology
  • Male
  • Middle Aged
  • Scleroderma, Systemic / pathology*
  • Scleroderma, Systemic / physiopathology
  • Skin / pathology*
  • Skin Physiological Phenomena
  • T-Lymphocytes / immunology
  • T-Lymphocytes / pathology
  • T-Lymphocytes / physiology


  • Antibodies, Monoclonal