7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist

J Med Chem. 1992 Sep 18;35(19):3578-81. doi: 10.1021/jm00097a016.
No abstract available

MeSH terms

  • Adamantane / analogs & derivatives*
  • Adamantane / chemical synthesis
  • Adamantane / metabolism
  • Adamantane / pharmacology
  • Adenosine / analogs & derivatives
  • Adenosine / pharmacology
  • Adenosine-5'-(N-ethylcarboxamide)
  • Animals
  • Guinea Pigs
  • Hemodynamics / drug effects
  • Imidazoles / chemical synthesis*
  • Imidazoles / metabolism
  • Imidazoles / pharmacology
  • Purinergic Antagonists*
  • Purinones / chemical synthesis*
  • Purinones / metabolism
  • Purinones / pharmacology
  • Rats
  • Receptors, Purinergic / metabolism
  • Solubility
  • Vasodilator Agents / pharmacology

Substances

  • Imidazoles
  • Purinergic Antagonists
  • Purinones
  • Receptors, Purinergic
  • Vasodilator Agents
  • KF 20274
  • Adenosine-5'-(N-ethylcarboxamide)
  • Adenosine
  • Adamantane