Effects of adenosine on canine penile erection

J Urol. 1992 Oct;148(4):1323-5. doi: 10.1016/s0022-5347(17)36901-x.


We investigated the hemodynamic effects of intracavernous injection of adenosine on canine penile erection. In all ten dogs studied, adenosine induced a dose-dependent increase of intracavernous pressure (ICP). Adenosine (0.67 to 15 micrograms/kg., B.W.) increased arterial blood flow by 83 to 325 percent above baseline levels and also increased venous resistance, which resulted in a full erection (ICP = 80 to 140 cm. H2O) for one to 7 minutes. The repeatability of the adenosine effect was confirmed in eight dogs. We found that adenosine, by virtue of its smooth muscle relaxation properties, can induce a dose-dependent increase of ICP and cause a full erection in dogs.

MeSH terms

  • Adenosine / pharmacology*
  • Animals
  • Dogs
  • Dose-Response Relationship, Drug
  • Male
  • Penile Erection / drug effects*
  • Penis / blood supply
  • Penis / drug effects
  • Pressure


  • Adenosine