Effect of age-related lipid peroxidation on membrane fluidity and phospholipase A2: modulation by dietary restriction

Mech Ageing Dev. 1992 Aug;65(1):17-33. doi: 10.1016/0047-6374(92)90123-u.


Age-related changes in membrane property are generally accepted phenomena. In this report, using the anti-lipoperoxidative measure of dietary restriction on membranes, the age-related effects of lipid peroxidation on membrane fluidity are explored in conjunction with the membrane-associated phospholipase A2. The fluidity of mitochondrial and microsomal membranes from ad libitum fed rats shows a progressive decline with age as indicated by a substantial decrease in two parameters, l/polarization and l/anisotropy. In contrast, the membrane fluidity of dietary restricted rats shows slight changes between 6 and 24 months of age. Evidence is presented to support the possibility that age-related peroxidation of membrane lipids may play a significant role in bringing about fluidity changes in aged membranes. The findings on the increased phospholipase A2 with age is also consistent with this conclusion.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging / metabolism*
  • Animals
  • Diet
  • Intracellular Membranes / metabolism
  • Lipid Peroxidation*
  • Male
  • Membrane Fluidity
  • Microsomes, Liver / metabolism
  • Mitochondria, Liver / metabolism
  • Phospholipases A / metabolism
  • Phospholipases A2
  • Rats
  • Rats, Inbred F344


  • Phospholipases A
  • Phospholipases A2