Increments of dietary linoleate raise liver arachidonate, but markedly reduce heart n-6 and n-3 fatty acids in the rat

Lipids. 1992 Aug;27(8):624-8. doi: 10.1007/BF02536121.


Four diets containing 20% of energy (en%) as fat and with linoleic acid contents of 1.9, 3.1, 7.7 and 10.1 en%, respectively, were fed to one-month-old male rats for three months. The fatty acid profiles and the levels of the major n-6 and n-3 fatty acids in the lipids of plasma, liver, heart and kidney were measured. We found that with increasing concentrations of 18:2n-6 in the diet, linoleic acid rose in plasma and in all organs, but long-chain n-6 and n-3 fatty acids responded differently. In liver, arachidonic acid increased and n-3 fatty acids were not significantly affected; in heart, both arachidonic and docosahexaenoic acids were progressively reduced; and in kidney, there was no change of n-6 and n-3. The results indicate that incremental changes in dietary linoleate affect the levels of polyunsaturated fatty acids in liver and extrahepatic organs differently.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arachidonic Acid / metabolism*
  • Dietary Fats, Unsaturated / administration & dosage
  • Dietary Fats, Unsaturated / pharmacology*
  • Docosahexaenoic Acids / metabolism
  • Eicosapentaenoic Acid / metabolism
  • Fatty Acids / blood
  • Fatty Acids / metabolism*
  • Kidney / metabolism
  • Linoleic Acid
  • Linoleic Acids / administration & dosage
  • Linoleic Acids / pharmacology*
  • Lipid Metabolism
  • Lipids / blood
  • Liver / drug effects
  • Liver / metabolism*
  • Male
  • Myocardium / metabolism*
  • Organ Specificity
  • Rats


  • Dietary Fats, Unsaturated
  • Fatty Acids
  • Linoleic Acids
  • Lipids
  • Docosahexaenoic Acids
  • Arachidonic Acid
  • Linoleic Acid
  • Eicosapentaenoic Acid