BALANCED INCOMPLETE BLOCK DESIGNS IN BIOLOGICAL ASSAY ILLUSTRATED BY THE ASSAY OF GASTRIN USING A YOUDEN SQUARE

Br J Pharmacol Chemother. 1963 Aug;21(1):67-77. doi: 10.1111/j.1476-5381.1963.tb01502.x.

Abstract

General equations are given for computing the results of any (j+j) dose parallel line biological assay based on an incomplete block design. Only the information from comparisons within blocks is used. The computation is illustrated numerically by means of a (2+2) assay of gastrin devised and performed by Lai (1962), in which only three of the four doses could be given to each animal.

MeSH terms

  • Animals
  • Biological Assay*
  • Gastrins*
  • Rats
  • Research*

Substances

  • Gastrins