MELATONIN SYNTHESIS IN THE PINEAL GLAND: CONTROL BY LIGHT

Science. 1963 Nov 22;142(3595):1071-3. doi: 10.1126/science.142.3595.1071.

Abstract

In rats placed in continuous darkness for 6 days, there is a striking increase in the activity of melatonin-synthesizing-enzyme (hydroxyindole-0-methyl transferase) in the pineal gland, but no change in the activity of monoamine oxidase. Since melatonin appears to have a hormonal role in mammals, and its synthesis is confined to the pineal gland, the inhibition of hydroxyindole-O-methyl transferase by light may constitute a mechanism of neuroendocrine regulation.

MeSH terms

  • Animals
  • Darkness*
  • Indoles*
  • Light*
  • Melatonin*
  • Metabolism*
  • Pineal Gland*
  • Rats
  • Research*
  • Transferases*

Substances

  • Indoles
  • indole
  • Transferases
  • Melatonin