The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition

Nature. 1992 Sep 24;359(6393):339-42. doi: 10.1038/359339a0.


The candidate oncogene bcl-3 was discovered as a translocation into the immunoglobulin alpha-locus in some cases of B-cell chronic lymphocytic leukaemias. The protein Bcl-3 contains seven so-called ankyrin repeats. Similar repeat motifs are found in a number of diverse regulatory proteins but the motifs of Bcl-3 are most closely related to those found in I kappa B proteins in which the ankyrin repeat domain is thought to be directly involved in inhibition of NF-kappa B activity. No biological function has yet been described for Bcl-3, but it was noted recently that Bcl-3 interferes with DNA-binding of the p50 subunit of NF-kappa B in vitro. Here we demonstrate that Bcl-3 can aid kappa B site-dependent transcription in vivo by counteracting the inhibitory effects of p50/NF-kappa B homodimers. Bcl-3 may therefore aid activation of select NF-kappa B-regulated genes, including those of the human immunodeficiency virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ankyrins / genetics
  • B-Cell Lymphoma 3 Protein
  • Cell Line
  • Cell Nucleus / metabolism
  • Chloramphenicol O-Acetyltransferase / genetics
  • Chloramphenicol O-Acetyltransferase / metabolism
  • Gene Expression
  • Glutathione Transferase / genetics
  • Glutathione Transferase / metabolism
  • HIV / genetics
  • HIV Long Terminal Repeat
  • Humans
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / metabolism*
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism*
  • Recombinant Fusion Proteins / metabolism
  • Repetitive Sequences, Nucleic Acid
  • T-Lymphocytes / metabolism
  • Transcription Factors
  • Transcription, Genetic
  • Transcriptional Activation
  • Transfection
  • Tumor Necrosis Factor-alpha / pharmacology


  • Ankyrins
  • B-Cell Lymphoma 3 Protein
  • BCL3 protein, human
  • NF-kappa B
  • Proto-Oncogene Proteins
  • Recombinant Fusion Proteins
  • Transcription Factors
  • Tumor Necrosis Factor-alpha
  • Chloramphenicol O-Acetyltransferase
  • Glutathione Transferase