Evolution of sex determination and the Y chromosome: SRY-related sequences in marsupials

Nature. 1992 Oct 8;359(6395):531-3. doi: 10.1038/359531a0.


In mammals, testis determination is under the control of the testis-determining factor borne by the Y chromosome. SRY, a gene cloned from the sex-determining region of the human Y chromosome, has been equated with the testis-determining factor in man and mouse. We have used a human SRY probe to identify and clone related genes from the Y chromosome of two marsupial species. Comparisons of eutherian and metatherian Y-located SRY sequences suggest rapid evolution of these genes, especially outside the region encoding the DNA-binding HMG box. The SRY homologues, together with the mouse Ube1y homologues, are the first genes to be identified on the marsupial Y chromosome.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Biological Evolution*
  • Conserved Sequence
  • DNA / chemistry
  • DNA Probes
  • DNA-Binding Proteins / genetics
  • Female
  • Humans
  • Kruppel-Like Transcription Factors
  • Male
  • Marsupialia / genetics*
  • Molecular Sequence Data
  • Sequence Homology, Nucleic Acid
  • Sex Determination Analysis*
  • Transcription Factors
  • Y Chromosome*


  • DNA Probes
  • DNA-Binding Proteins
  • Kruppel-Like Transcription Factors
  • Transcription Factors
  • ZFY protein, human
  • DNA