Creative blocks: cell-cycle checkpoints and feedback controls

Nature. 1992 Oct 15;359(6396):599-604. doi: 10.1038/359599a0.


Before division, cells must ensure that they finish DNA replication, DNA repair and chromosome segregation. They do so by using feedback controls which can detect the failure to complete replication, repair or spindle assembly to arrest the progress of the cell cycle at one of three checkpoints. Failures in feedback controls can contribute to the generation of cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle / genetics
  • Cell Cycle / physiology*
  • Chromosomes / physiology
  • DNA Repair / physiology
  • DNA Replication / physiology
  • Eukaryotic Cells
  • Feedback / physiology
  • Humans
  • Neoplasms / genetics