[In vitro effect of serotonin on the enzyme activities of glutamate decarbosylase and GABA transaminase at the level of acellular preparations of rat mesencephalon synaptosomes]

M F Belin; J C Kouyoumdjian; P Gonnard; M Jouvet

[In vitro effect of serotonin on the enzyme activities of glutamate decarbosylase and GABA transaminase at the level of acellular preparations of rat mesencephalon synaptosomes]

C R Seances Soc Biol Fil. 1976;170(6):1243-7.

[Article in French]

Authors

M F Belin, J C Kouyoumdjian, P Gonnard, M Jouvet

PMID: 140743

Abstract

The effect of serotonin on glutamate decarboxylase and GABA-transaminase was studied, in vitro, in synaptosome homogenates from rat mesencephalon. Serotonin dissolved in the incubation medium inhibits glutamate decarboxylase activity and stimulates GABA-transaminase activity.

Publication types

English Abstract

MeSH terms

Animals
Carboxy-Lyases / metabolism*
Glutamate Decarboxylase / metabolism*
In Vitro Techniques
Male
Mesencephalon / enzymology*
Rats
Serotonin / pharmacology*
Synaptosomes / drug effects
Synaptosomes / enzymology*
Transaminases / metabolism*
gamma-Aminobutyric Acid

Substances

Serotonin
gamma-Aminobutyric Acid
Transaminases
Carboxy-Lyases
Glutamate Decarboxylase