Positron emission tomography-guided stereotactic brain biopsy

Neurosurgery. 1992 Oct;31(4):792-7; discussion 797. doi: 10.1227/00006123-199210000-00029.


We describe a technique that allows target definition for stereotactic brain biopsy using coordinates calculated on stereotactic positron emission tomographic (PET) images. In this study, PET images were obtained using [18F]-labeled fluorodeoxyglucose, a marker for glucose metabolism. The difference between PET-calculated and actual stereotactic coordinates of simulated targets is within PET spatial resolution. Combined computed tomography- and PET-guided stereotactic biopsies were performed in 11 patients with brain tumors. In this report, we describe two representative patients who underwent stereotactic brain biopsy using the present technique. Because of the complementary role of PET and computed tomography, their integration in multimodality planning might optimize the target selection for stereotactic brain biopsies.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Astrocytoma / diagnostic imaging
  • Astrocytoma / pathology
  • Biopsy / instrumentation*
  • Blood Glucose / metabolism
  • Brain / diagnostic imaging
  • Brain / pathology*
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / pathology*
  • Deoxyglucose / analogs & derivatives
  • Deoxyglucose / metabolism
  • Energy Metabolism / physiology*
  • Fluorodeoxyglucose F18
  • Humans
  • Middle Aged
  • Models, Anatomic
  • Stereotaxic Techniques / instrumentation*
  • Tomography, Emission-Computed / instrumentation*


  • Blood Glucose
  • Fluorodeoxyglucose F18
  • Deoxyglucose