Brain abnormalities in male children and adolescents with hemophilia: detection with MR imaging. The Hemophilia Growth and Development Study Group

Radiology. 1992 Nov;185(2):553-8. doi: 10.1148/radiology.185.2.1410372.


Cranial magnetic resonance (MR) imaging was performed in 124 male patients (aged 7-19 years), from 14 institutions, in whom a diagnosis of moderate to severe hemophilia was made. Blood tests in all subjects were negative for human immunodeficiency virus. Findings in MR studies were abnormal in 25 (20.2%) subjects. Six lesions in five subjects were classified as congenital. The most commonly identified congenital lesion was a posterior fossa collection of cerebrospinal fluid (five cases). Twenty-two subjects had acquired lesions that were probably related to the hemophilia or its treatment. The most commonly acquired lesions were single- or multifocal areas of high signal intensity within the white matter on T2-weighted images noted in 14 (11.3%) subjects. Two subjects had large focal areas of brain atrophy, and six had some degree of diffuse cerebral cortical atrophy. Three subjects (2.4%) had hemorrhagic lesions. To the authors' knowledge, the unexpected finding of small, focal, nonhemorrhagic white matter lesions has not previously been reported.

Publication types

  • Multicenter Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Atrophy
  • Brain / pathology*
  • Brain Diseases / diagnosis*
  • Cerebral Hemorrhage / pathology
  • Child
  • HIV Seropositivity
  • Hemophilia A / classification
  • Hemophilia A / pathology*
  • Hemophilia B / pathology
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Neurologic Examination
  • Prevalence
  • Seizures / pathology
  • von Willebrand Diseases / pathology