Sensitivity and specificity for correlated observations

Stat Med. 1992 Aug;11(11):1503-9. doi: 10.1002/sim.4780111108.


A general estimating equation approach is used to obtain estimates of sensitivity and specificity when the data consist of correlated binary outcomes. First order approximations to the variances of estimated sensitivity and specificity for prospective and retrospective studies are given. Data from a dental study are used to motivate and illustrate the methods.

MeSH terms

  • Cluster Analysis
  • Humans
  • Models, Statistical*
  • Predictive Value of Tests*
  • Prospective Studies
  • Retrospective Studies
  • Sensitivity and Specificity*