E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

Science. 1992 Oct 16;258(5081):424-9. doi: 10.1126/science.1411535.

Abstract

The cellular transcription factor E2F, previously identified as a component of early adenovirus transcription, has now been shown to be important in cell proliferation control. E2F appears to be a functional target for the action of the tumor suppressor protein Rb that is encoded by the retinoblastoma susceptibility gene. The disruption of this E2F-Rb interaction, as well as a complex involving E2F in association with the cell cycle-regulated cyclin A-cdk2 kinase complex, may be a common mechanism of action for the oncoproteins encoded by the DNA tumor viruses.

MeSH terms

  • Adenovirus E1A Proteins / metabolism
  • Adenoviruses, Human / genetics
  • Binding Sites
  • Carrier Proteins*
  • Cell Cycle
  • Cell Cycle Proteins*
  • Cell Transformation, Viral*
  • Cloning, Molecular
  • DNA-Binding Proteins / metabolism
  • E2F Transcription Factors
  • Gene Expression Regulation, Viral*
  • Genes, Tumor Suppressor
  • Humans
  • Oncogene Proteins, Viral / metabolism*
  • Protein Binding
  • Regulatory Sequences, Nucleic Acid
  • Retinoblastoma Protein / metabolism*
  • Retinoblastoma-Binding Protein 1
  • Transcription Factor DP1
  • Transcription Factors / metabolism*

Substances

  • Adenovirus E1A Proteins
  • Carrier Proteins
  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • E2F Transcription Factors
  • Oncogene Proteins, Viral
  • Retinoblastoma Protein
  • Retinoblastoma-Binding Protein 1
  • Transcription Factor DP1
  • Transcription Factors