Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14

Science. 1992 Oct 23;258(5082):668-71. doi: 10.1126/science.1411576.


Linkage analysis was used to search the genome for chromosomal regions harboring familial Alzheimer's disease genes. Markers on chromosome 14 gave highly significant positive lod scores in early-onset non-Volga German kindreds; a Zmax of 9.15 (theta = 0.01) was obtained with the marker D14S43 at 14q24.3. One early-onset family yielded a lod score of 4.89 (theta = 0.0). When no assumptions were made about age-dependent penetrance, significant results were still obtained (Zmax = 5.94, theta = 0.0), despite the loss of power to detect linkage under these conditions. Results for the Volga German families were either negative or nonsignificant for markers in this region. Thus, evidence indicates a familial Alzheimer's disease locus on chromosome 14.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alzheimer Disease / genetics*
  • Base Sequence
  • Chromosomes, Human, Pair 14*
  • Female
  • Genetic Linkage / genetics*
  • Humans
  • Male
  • Molecular Sequence Data
  • Oligonucleotide Probes / genetics
  • Pedigree


  • Oligonucleotide Probes