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. 1992 Oct;63(1):13-20.
doi: 10.1016/0378-4274(92)90103-q.

Protective Effect of Copper Against Cadmium Cytotoxicity on Cultured Vascular Endothelial Cells

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Protective Effect of Copper Against Cadmium Cytotoxicity on Cultured Vascular Endothelial Cells

T Kaji et al. Toxicol Lett. .

Abstract

We investigated the effect of copper on cadmium-induced cytotoxicity on vascular endothelial cells from bovine aorta in a culture system. Cytotoxicity was evaluated by the [3H]adenine release assay and the histological observation. After a 24-h incubation, cadmium exhibited a significant cytotoxicity on confluent cultures of endothelial cells in a dose-dependent manner, while copper only slightly did after a 24-h incubation. It was found that copper (5 microM) significantly decreased cadmium (1 and 2 microM) cytotoxicity; histologically, formation of de-endothelialized areas in the cell layer caused by cadmium was reduced by copper. The accumulation of cadmium in the cell layer was significantly decreased by copper; however, that of copper was unaffected by cadmium. It was therefore suggested that copper significantly protects cadmium-induced cytotoxicity on cultured endothelial cells primarily through decreasing the cellular cadmium accumulation.

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