SEROTONIN DEFICIENCY IN INFANCY AS ONE CAUSE OF A MENTAL DEFECT IN PHENYLKETONURIA

Science. 1964 May 15;144(3620):883-4. doi: 10.1126/science.144.3620.883.

Abstract

Serotonin deficiency induced in newborn mice and maintained to adulthoodresulted in reduced ability to learn a maze. The serotonin deficiency was produced by overloading with phenylalanine plus tyrosine (to cause phenylketonuria), by feeding of reserpine, and by feeding of chlorpro mazine from birth to maturity.

MeSH terms

  • Animals
  • Animals, Newborn*
  • Behavior*
  • Catecholamines*
  • Chlorpromazine / toxicity*
  • Genetics*
  • Learning*
  • Metabolic Diseases*
  • Metabolism*
  • Mice
  • Phenylalanine*
  • Phenylketonurias*
  • Phenylpyruvic Acids*
  • Research*
  • Reserpine / toxicity*
  • Serotonin*
  • Toxicology*
  • Tyrosine*

Substances

  • Catecholamines
  • Phenylpyruvic Acids
  • Serotonin
  • Tyrosine
  • Phenylalanine
  • Reserpine
  • Chlorpromazine
  • phenylpyruvic acid