Left ventricular filling abnormalities in non-insulin-dependent diabetes mellitus and improvement by a short-term glycemic control

Am J Cardiol. 1992 Nov 1;70(13):1185-9. doi: 10.1016/0002-9149(92)90053-2.


To determine whether left ventricular (LV) filling abnormalities in diabetes are associated with diabetic microangiopathy, and to evaluate the effect of a short-term glycemic control on the filling abnormalities, diastolic filling dynamics were assessed by pulsed Doppler echocardiography in 246 patients with non-insulin-dependent diabetics. Isovolumic relaxation time and the ratio of peak flow velocity of atrial filling wave to peak flow velocity of early filling wave (A/E) were significantly greater in diabetic patients than in age- and sex-matched control subjects. Diabetic patients with retinopathy had significantly greater isovolumic relaxation time and A/E values than those without retinopathy. A/E was significantly decreased 1 month after insulin treatment in those without, but not with retinopathy. It is concluded that LV diastolic filling is impaired in mildly hyperglycemic patients with non-insulin-dependent diabetes mellitus without severe complications, the abnormality being more intense in patients with retinopathy. A short-term glycemic control results in a marked decrease in abnormalities in patients without, but not with retinopathy.

MeSH terms

  • Adult
  • Aged
  • Analysis of Variance
  • Blood Flow Velocity / physiology
  • Chi-Square Distribution
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / diagnostic imaging
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Diabetic Retinopathy / diagnostic imaging
  • Diabetic Retinopathy / physiopathology
  • Diastole
  • Echocardiography / methods
  • Female
  • Humans
  • Hyperglycemia / drug therapy
  • Hyperglycemia / etiology
  • Hyperglycemia / physiopathology*
  • Insulin / therapeutic use
  • Male
  • Middle Aged
  • Ventricular Function, Left / physiology*


  • Insulin