Retinal hemorrhages in newborn piglets following cardiopulmonary resuscitation

Am J Dis Child. 1992 Nov;146(11):1294-6. doi: 10.1001/archpedi.1992.02160230052014.


Objective: To determine whether conventional cardiopulmonary resuscitation causes retinal hemorrhages in piglets.

Design: Nonrandomized observations.

Setting: Animal physiology laboratory.

Participants: Six 3.5- to 4.5-kg piglets.

Interventions: Fifty minutes of conventional, closed chest cardiopulmonary resuscitation.

Measurements/main results: Intrathoracic venous pressure (right atrium) and intracranial venous pressure (sagittal sinus) were directly measured. At 5 minutes of cardiopulmonary resuscitation, the mean (+/- SEM) sagittal sinus pressure was 41 +/- 8 mm Hg and the mean right atrial pressure was 58 +/- 9 mm Hg. The pressures were sustained throughout the 50 minutes of cardiopulmonary resuscitation. At autopsy, there was no gross or microscopic evidence of retinal hemorrhages.

Conclusion: These results support the conclusion that cardiopulmonary resuscitation does not cause retinal hemorrhages.

MeSH terms

  • Animals
  • Animals, Newborn
  • Cardiopulmonary Resuscitation / adverse effects*
  • Hemodynamics
  • Retinal Hemorrhage / etiology*
  • Swine