Smoking does not contribute to duodenal ulcer relapse after Helicobacter pylori eradication

Am J Gastroenterol. 1992 Oct;87(10):1390-3.


Cigarette smoking is believed to be one of the major factors influencing duodenal ulcer (DU) recurrence. However, the influence of cigarette smoking on DU recurrence after the eradication of Helicobacter pylori has not been separately addressed. The aim of this study was to investigate DU relapse rate in smokers and nonsmokers, both with confirmed eradication of H. pylori. Patients with H. pylori eradication, demonstrated at endoscopy 4 wk post-treatment, were included in the study. Smoking history was obtained with a standard questionnaire, and patients were followed endoscopically, both yearly and at symptomatic recurrence, to detect anatomical DU recurrence. Of the 197 (121M:76F) patients enrolled in the study and followed for 1-6 yr, 80 (41%) were smokers, smoking 5-40 cigarettes/day. The 117 (59%) nonsmokers included 31 (26%) patients who had ceased smoking 4-20 yr ago. Another seven (9%) smokers ceased smoking during the follow-up period. In the 197 patients with eradicated H. pylori and cured DU, there has been no recurrence of ulcer, regardless of smoking status. We conclude that in patients with DU in whom H. pylori infection is eradicated, ulcer disease does not recur, as observed for up to 6 yr. Furthermore, cigarette smoking is not a risk factor for DU recurrence, provided H. pylori is eradicated.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Ulcer Agents / therapeutic use
  • Duodenal Ulcer / drug therapy
  • Duodenal Ulcer / epidemiology
  • Duodenal Ulcer / microbiology*
  • Female
  • Follow-Up Studies
  • Helicobacter Infections / drug therapy*
  • Helicobacter Infections / epidemiology
  • Helicobacter pylori / isolation & purification*
  • Humans
  • Male
  • Metronidazole / therapeutic use
  • Middle Aged
  • Organometallic Compounds / therapeutic use
  • Recurrence
  • Risk Factors
  • Smoking / epidemiology*
  • Tetracycline / therapeutic use
  • Time Factors


  • Anti-Ulcer Agents
  • Organometallic Compounds
  • Metronidazole
  • Tetracycline
  • bismuth tripotassium dicitrate