Serum gastrin is not higher in subjects with colonic neoplasia

Am J Gastroenterol. 1992 Oct;87(10):1394-7.


Two previous studies have shown higher circulating gastrin levels in subjects with colonic neoplasia than in colonoscopy-negative controls. In this much larger study, sera were collected from fasting subjects undergoing colonoscopy. Colonoscopy with biopsy classified participants as having colonic adenomas (N = 139), colon carcinoma (N = 29), or controls without colonic neoplasia (N = 150). Frozen, stored sera were later analyzed for gastrin by radioimmunoassay. Serum gastrin values were no higher in subjects with colonic adenomas or carcinoma than in colonoscopy-negative controls. We conclude that elevated serum gastrin levels play little, if any, role in the initiation of colonic neoplasia.

MeSH terms

  • Adenocarcinoma / blood
  • Adenocarcinoma / diagnosis
  • Adenocarcinoma / epidemiology
  • Adenoma / blood*
  • Adenoma / diagnosis
  • Adenoma / epidemiology
  • Case-Control Studies
  • Colonic Neoplasms / blood*
  • Colonic Neoplasms / diagnosis
  • Colonic Neoplasms / epidemiology
  • Colonoscopy
  • Female
  • Gastrins / blood*
  • Humans
  • Male
  • Middle Aged
  • Radioimmunoassay


  • Gastrins