Am J Med Sci. 1992 Oct;304(4):261-7. doi: 10.1097/00000441-199210000-00008.


Loxoscelism, or envenomation by the brown recluse spider, may result in necrotic lesions and systemic reactions, including hemolytic anemia. Histologically, it resembles a cutaneous Arthus reaction. The reaction mechanism involves interactions between complement, neutrophils, and the clotting system. It is best treated with analgesics, avoidance of early surgical debridement, and oral dapsone.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Spider Bites / physiopathology*
  • Spider Bites / prevention & control
  • Spider Bites / therapy
  • Spiders*