The expression of the Hu (paraneoplastic encephalomyelitis/sensory neuronopathy) antigen in human normal and tumor tissues

Am J Pathol. 1992 Oct;141(4):881-6.


Using immunohistochemistry or Western blot analysis, the authors have studied the expression of the Hu antigen (a neuronal protein identified by the serum of patients with small cell lung cancer and paraneoplastic encephalomyelitis/sensory neuronopathy) in normal human tissues and 115 tumors of different histologic types. In normal tissue, the Hu antigen is highly restricted to the nervous system. In lung tumors, the Hu antigen is restricted in its expression to all small cell carcinomas. A few other neuroendocrine-related tumors, especially neuroblastomas (50%), also express the antigen.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Carcinoma, Small Cell / immunology
  • ELAV Proteins
  • Encephalomyelitis / immunology*
  • Humans
  • Neoplasms / immunology*
  • Nerve Tissue Proteins / biosynthesis
  • Paraneoplastic Syndromes / immunology*
  • RNA-Binding Proteins / biosynthesis*


  • ELAV Proteins
  • Nerve Tissue Proteins
  • RNA-Binding Proteins