Muscle protein breakdown during endotoxemia in rats and after treatment with interleukin-1 receptor antagonist (IL-1ra)

Ann Surg. 1992 Sep;216(3):381-5; discussion 386-7. doi: 10.1097/00000658-199209000-00018.


The purpose of this study was to examine the effect of endotoxemia on muscle protein degradation and to test the hypothesis that muscle proteolysis during endotoxemia is regulated by interleukin-1 (IL-1). Both total and myofibrillar protein breakdown rates in incubated extensor digitorum longus muscles were increased after the subcutaneous injection of 0.1 or 1.0 mg/kg endotoxin in rats. The endotoxin-induced increase in muscle protein breakdown was blunted by IL-1 receptor antagonist, administered intraperitoneally at a total dose of 45 or 105 mg/kg. Results suggest that endotoxemia in rats gives rise to sepsislike changes in muscle protein breakdown. Increased muscle protein breakdown during endotoxemia may be regulated, at least in part, by IL-1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Endotoxins
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1 / physiology*
  • Muscle Proteins / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Recombinant Proteins
  • Shock, Septic / chemically induced
  • Shock, Septic / metabolism*
  • Shock, Septic / therapy*
  • Sialoglycoproteins / pharmacology*


  • Endotoxins
  • Interleukin 1 Receptor Antagonist Protein
  • Interleukin-1
  • Muscle Proteins
  • Recombinant Proteins
  • Sialoglycoproteins