Effects of chronic ethanol administration on free radical defence in rat myocardium

Biochem Pharmacol. 1992 Oct 20;44(8):1495-500. doi: 10.1016/0006-2952(92)90463-s.


Cellular protection against free radical reactions was measured in myocardium from ethanol-fed rats using ethanol administration in drinking water as a model of moderate alcohol intoxication. The activities of Cu,Zn-superoxide dismutase (SOD) and glutathione-S-transferase were higher in ethanol-fed rats than in controls, whereas Mn-SOD, catalase and glutathione peroxidase activities were not altered by ethanol treatment. Myocardial zinc was higher and selenium concentration lower in ethanol-fed rats than in controls. Ethanol consumption, which failed to modify the myocardial vitamin E level, did not result in increased lipid peroxidation, but decreased cytosolic and membraneous protein thiols.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol Drinking*
  • Animals
  • Antioxidants / metabolism*
  • Ethanol / administration & dosage
  • Ethanol / pharmacology*
  • Free Radicals
  • Heart / drug effects*
  • Male
  • Myocardium / metabolism*
  • Proteins / analysis
  • Rats
  • Rats, Sprague-Dawley
  • Subcellular Fractions / metabolism
  • Sulfhydryl Compounds / analysis
  • Superoxide Dismutase / analysis
  • Thiobarbituric Acid Reactive Substances / analysis


  • Antioxidants
  • Free Radicals
  • Proteins
  • Sulfhydryl Compounds
  • Thiobarbituric Acid Reactive Substances
  • Ethanol
  • Superoxide Dismutase