Induction of TH1 and TH2 responses: a key role for the 'natural' immune response?

Immunol Today. 1992 Oct;13(10):379-81. doi: 10.1016/0167-5699(92)90083-J.


What pushes a T-cell response towards a predominantly TH1 or TH2 phenotype? Several factors have been proposed, including the properties of antigens, dose of antigen, site of exposure and ongoing immune response in the host. Here, Sergio Romagnani presents new evidence to indicate a determining role for the 'natural' immune response, including NK cells and cells of the mast cell/basophil lineage, in the subsequent 'specific' T-cell response.

Publication types

  • Review

MeSH terms

  • Animals
  • Basophils / immunology
  • Cytokines / biosynthesis
  • Humans
  • Immunity, Innate
  • Immunophenotyping
  • Killer Cells, Natural / immunology
  • Mast Cells / immunology
  • T-Lymphocytes, Helper-Inducer / immunology*


  • Cytokines