Diseases associated with HTLV-I: virus, IL-2 receptor dysregulation and redox regulation

Immunol Today. 1992 Oct;13(10):405-11. doi: 10.1016/0167-5699(92)90091-K.


HTLV-I, the etiological agent in adult T-cell leukemia, has also been strongly implicated in a number of non-neoplastic T-cell-associated diseases. Here, Junji Yodoi and Takashi Uchiyama review these associations and focus on the emerging concepts of IL-2R dysregulation and redox regulation by adult T-cell leukemia-derived factor in the pathogenesis of HTLV-I-related diseases.

Publication types

  • Review

MeSH terms

  • Gene Products, tax / immunology
  • HTLV-I Antibodies / immunology
  • HTLV-I Infections / genetics
  • HTLV-I Infections / immunology*
  • Human T-lymphotropic virus 1 / immunology*
  • Humans
  • Lymphocyte Activation
  • Oxidation-Reduction
  • Receptors, Interleukin-2 / immunology*
  • T-Lymphocytes / immunology


  • Gene Products, tax
  • HTLV-I Antibodies
  • Receptors, Interleukin-2