Costimulation of T-cell growth

Curr Opin Immunol. 1992 Jun;4(3):265-70. doi: 10.1016/0952-7915(92)90075-p.


The specificity of T-cell recognition is dictated by the interaction of the T-cell receptor with MHC-peptide complexes. The biological consequences of such recognition is determined, however, by costimulatory pathway(s). Recent studies have led to the identification of receptor-counter-receptor pairs that may regulate T-cell costimulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Adhesion Molecules / physiology
  • Immune Tolerance / physiology
  • Lymphocyte Activation / physiology*
  • Receptors, Antigen, T-Cell / immunology
  • T-Lymphocytes / immunology*


  • Cell Adhesion Molecules
  • Receptors, Antigen, T-Cell